Pharma Applications

Colony counters and zone measuring systems for accurate microbial enumeration or inhibition zone sizing to test the efficacy or sterility of  pharmaceutical samples. 

Synbiosis has developed world-leading colony counting and inhibition zone measurement technology since 1985 to bring you the innovative ProtoCOL 3, Protos 3 and aCOLyte 3 systems. Within these ranges you’ll find the ideal colony counter or zone sizing system to suit your budget and applications.

Fast colony counts
Synbiosis offers ProtoCOL 3, Protos 3 or an aCOLyte 3 for microbial limits testing with any pharmaceutical sample to accurately count bacteria and yeast colonies from serial dilutions on spiral plates and membranes on plates post membrane filtration. The systems will rapidly provide you with a precise total viable count (TVC/TVAC) making them ideal for applications such as disinfectant testing and media quality control. The ProtoCOL 3 can also be used in a GMP environment for validation of the bioburden in ingredients and finished pharmaceuticals by safety testing including Ames, stability and preservative efficacy testing.

Exceptional colour differentiation
With Synbiosis ProtoCOL 3 and Protos 3’s unrivalled colour differentiation technology you can count pathogens such as Staphylococcus and E.coli on selective agar, quickly and easily. The ProtoCOL 3 system’s colour analysis is so impressive it can be used in vaccine testing, to deliver precise counts of minute red colonies post OPKA (opsonophagocytic killing assay) or SBA (serum bactericidal assay).

Easy zone measurement
The Synbiosis ProtoCOL 3 system is ideal if you’re using microbial inhibition in vaccine or antibiotic manufacture as a measure of efficacy. ProtoCOL 3 saves you time and effort by automating zone sizing of single radial immunodiffusion (SRD) plates and antibiotic susceptibility testing methods.

Rapid analysis
With the simple to use software in Synbiosis systems, you can automatically count colonies and produce zone measurements, effortlessly providing you with realistic images and accurate data in seconds. The ProtoCOL 3 software can be integrated into a 21CFR Part 11 environment making it easy to achieve GLP and GMP compliance.

Click on the following links to download pdfs from Synbiosis on the following applications:




Moisture readings play a crucial role in processes such as powder drying, granulation and hard gelatine capsules. 

It is easy to understand why TEWS puts as much stress on the quality of products, raw materials and processes as the pharmaceutical industry. When it comes to precision and speed, measuring must meet the very highest standards.

Powder drying and granulation
Moisture readings play a crucial role in processes such as powder drying and granulation. Drying is best controlled if accurate sensor values are always available. You may, for example, wish to measure the moisture as the material is inserted in a spray dryer. Taking continuous readings can help you determine when the process has achieved its target moisture. Thus, drying and granulation can be monitored properly.

Hard gelatine capsules
The properties of hard gelatine capsules depend on moisture to a very high degree. Prior to automatic filling, the capsules need to be conditioned to attain a specific moisture level to ensure their physical properties are optimized.

Moisture content can be measured online in the dryer in order to verify whether the capsule moisture is met for further processing. Automatic sampling is carried out in a bypass system to monitor the hard gelatine capsules. The moisture in the pressed powder could also be measured when the tablet is inserted in the pressing machine.

100% inspection of tablets and capsulesAs the production of pharmaceuticals has a tendency to increase continuous production control and documentation, there is a constant growing demand for 100% monitoring of all the weight in tablets produced and filled capsules. The weights cannot be monitored 100% by using balances at the speed of modern production lines.

The TEWS Elektronik MW 3011 microwave instrument returns 10,000 moisture and mass readings every second, therefore making it the perfect tool for the high-speed separate measurement of rapidly passing tablets and capsules. The number of objects measured per instrument of time is limited solely by the speed at which the objects are passed through the sensor - not by the measuring frequency. Microwave resonance sensors can be installed directly into the production machine or can operate in separate inspection equipment.

TEWS application PDF HERE







Cole Parmer is a market-leading manufacturer of benchtop science equipment which for the pharmaceutical industry are GMP compliant features, Easy to use,  Robust & Excellent value for money.


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Peristaltic pumps – the contamination-free pumping technology favored by regulated industries.

Our BioConnect and Custom Cut Tubing services are ready to provide you with custom gamma-irradiated single-use tubing assemblies and tubing cut to the lengths and quantities you need. In addition to the products we offer, our representatives are familiar with the challenges you face and the services you require

Tangential Flow Filtration

Cole-Parmer offers the pumps, fluid path tubing and connectors, filtration, pressure monitors, and more products to ensure success while protecting the purity of your end products.


Pumps, fluid path components, mixing equipment, filtration, and process monitoring are all important pieces of a complete buffer preparation system.


Peristaltic pumps, with sterilized tubing, connectors, are ideal methods to protect the purity of your culture when transferring between production vessels.